Clinical Overview
Restera’s clinical team in Australia, the US, and Europe continues to demonstrate the effectiveness of our approach for treatment for OSA in international studies
IM-001
Acute Proof-of-Concept Study to Evaluate HGN Stimulation in Humans with OSA
We proposed a novel idea: based on our team’s experience we believe placement of a stimulation array through a needle on the HGN guided by ultrasound is possible. IM-001 was conducted to verify this idea.
In this study, we demonstrated success in acutely placing a neurostimulation lead in position through the use of a needle and ultrasound.
International Surgical Sleep Society Poster 2024
Percutaneous Approaches to Hypoglossal Nerve Stimulation
American Academy of Otolaryngology Head and Neck Surgery Journal Article 2024
Percutaneous Approaches to Hypoglossal Nerve Stimulation Publication
IM-002
Acute Proof-of-Concept Study to Evaluate Hypoglossal Nerve Stimulation in Humans with Obstructive Sleep Apnea
Placing a stimulation array in different areas of a nerve yields different results. We believe that we have found a superior placement. IM-002 was conducted to verify the effectiveness of our patented placement.
In this study, we demonstrated that an improved approach to the HGN can provide significantly improved results, surpassing expectations.
A novel hypoglossal nerve stimulation approach restores upper airway function and airflow to therapeutic CPAP levels in people with obstructive sleep apnea
American Thoracic Society Poster 2024
Journal Article in CHEST, September 2025
Novel hypoglossal stimulation markedly improves airflow and airway collapsibility in OSA
IM-005
Multicenter Proof-of-Concept Study to Investigate the Feasibility and Respiratory Effects of Stimulating Two Functional Targets (Neural and/or Muscular) for the Treatment of Obstructive Sleep Apnea
We believe that the Ansa Cervicalis nerve provides an additional option for delivery of therapy. IM-005 was conducted to identify the optimal location and verify the effectiveness of neurostimulation of the AC.
In this study, we demonstrated that there are additional improvements possible by including the Ansa Cervicalis as well as the HGN.
Sleep Down Under Abstract 2024 (IM-005 Study)
Targeted ansa cervicalis nerve stimulation restores airflow to airway narrowing in obstructive sleep apnoea during propofol anaesthesia
